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In-host mechanisms

Apr 27, 2020

Publications

Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines

David Hodgson, Yi Liu, Louise Carolan, Siddhartha Mahanty, Kanta Subbarao, Sheena G. Sullivan, Annette Fox, Adam Kucharski

July 2024 Preprint

This study compares immune responses between ChAdOx1 (Adenovirus-based) and BNT162b2 (mRNA) COVID-19 vaccines. It finds that mRNA vaccines induce significantly higher memory B cell proliferation and longer-lasting antibody responses than Adenovirus vaccines, especially with extended dosing intervals.

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