Immunology

This study compares immune responses between ChAdOx1 (Adenovirus-based) and BNT162b2 (mRNA) COVID-19 vaccines. It finds that mRNA vaccines induce significantly higher memory B cell proliferation and longer-lasting antibody responses than Adenovirus vaccines, especially with extended dosing intervals.

This study explores how pre-vaccination HAI titres and vaccination history influence post-vaccine antibody responses in influenza vaccines. It finds that individuals with lower pre-vaccine antibody levels experience a larger and longer-lasting antibody boost after vaccination, while frequent vaccine recipients show a diminished response. The study emphasizes the importance of considering individual pre-vaccine antibody levels and vaccine history when interpreting post-vaccination antibody dynamics.